Gut reaction

نویسندگان

  • Robert Wallin
  • Birger Christensson
  • Hans-Gustaf Ljunggren
چکیده

The image above shows immunofluorescence staining of a cross-section of small intestine from a mouse with a 'mosaic' pattern of expression of cell-surface MHC (major histocompatibility complex) class I molecules. The mosaic effect can be seen on the intestinal villi, which contain stretches of epithelial cells that express MHC class I (bright green) interrupted by equally long stretches of cells deficient in MHC class I (dark green). The cell nuclei are counter-stained (purple and light blue). All the tissues studied in this mouse show mosaic expression of MHC class I molecules. Studies of such MHC class I mosaic mice have provided new insights into the role of MHC class I molecules in host immune defence against 'foreign' proteins. In particular, they are elucidating the poorly understood mechanism by which expression of MHC class I protects normal host cells against the body's own so-called 'natural killer' cells. Host cells lacking MHC class I molecules (for example those infected by virus) are a target for natural killer cells.

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عنوان ژورنال:
  • Current Biology

دوره 8  شماره 

صفحات  -

تاریخ انتشار 1998